试管婴儿:受精障碍患者的又一“生”路
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对于患有不孕症家庭来说,孩子是遥不可及的事情。对于出现受精障碍的家庭,试管婴儿或者是一条可行之路,对于这样的家庭,试管婴儿也是目前最快最有效的办法了。
试管婴儿:受精障碍患者的又一“生”路
受精卵障碍发生率和原因:
试管婴儿技术是治疗不孕症的辅助生殖技术之一,主要适用于女方因素导致的输卵管障碍、卵巢功能异常、子宫内膜异位症,对于男方来说就是少、弱、畸形精子以及不明原因的不孕情况等等。
有相关研究表明,在试管辅助生育技术治疗过程中,有10%—15%的家庭会出现受精障碍问题,当然其中也包括受精率低下和完全受精失败等情况。从精子穿过卵球开始,经历精子透明带发生的一切反应,直到最终原核的形成,精子和卵子任何一方都会有可能引发受精障碍。
受精障碍的高危因素:
有临床的研究表明,在年纪、不孕年龄、促排方案、获得卵子数、卵子成熟机率没有明显差异的情况下,有受精障碍患者是属于男性因素或者是不明原因不孕比例均高于受精正常组。这就表明男性少、弱、畸精子症以及不明原因不孕症患者发生受精障碍风险更高。
在精液常规分析的各项指标中,畸形率偏高和活动力低下与精子功能障碍关系更加密切,但是有相关研究表明,在精液常规分析结果正常的不明原因不育的患者中,仍然存在13%的精子与透明带结合障碍,而可以结合但诱发顶体反应缺陷者占28%,所以他们试管成功几率也并不高。
受精障碍的治疗策略:
对于存在受精障碍的患者来说,试管婴儿辅助生育是比较有效的治疗办法,当然还需要结合自身的情况综合考虑具体选择哪种方式。对于精子异常的患者,单精子卵浆内注射,也就是第二代试管婴儿是重要的手段,这种办法可以解决精子穿入障碍的问题。
- 当男性精子浓度小、活力低、功能性障碍导致精子穿入困难的时候,单精子卵浆内注射就显得格外的重要以及合适,并且在长期的临床试验中发现,这种办法能大大提高卵子受精的成功率。
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